Biologically active polycycloalkanes. 4. Phosphoric esters of trimethylenenorbornyl alcohols
- 31 October 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (11) , 1371-1374
- https://doi.org/10.1021/jm00221a003
Abstract
Secondary (6) and tertiary (8) phosphates of exo-5,6-trimethylenenorborn-exo-2-yl alcohol (exo-tricyclo-[5.2.1.02,6]dec-exo-8-yl alcohol, (3) and a secondary ester (9) of a mixture of exo-tricyclo[5.2.1.02,6]dec-3-en-8- and -9-yl alcohol were prepared. The most convenient route to 6 was direct esterification of phosphoric acid with 3. Ester 9 was obtainable by the addition of phosphoric acid to endo-dicyclopentadiene. These phosphates were tested in vitro for antiviral activity against Newcastle disease virus using a monolayer culture of chick embryo fibroblasts. Phosphate 6 was about twice more potent than, while 8 was as active as, amantadine hydrochloride under the present test conditions.Keywords
This publication has 1 reference indexed in Scilit:
- Plant growth retardant activity of 4-homoisotwistane derivativesPhytochemistry, 1977