Infection of cultured human type II pneumonocytes with certain respiratory viruses

Publisher Website
Google Scholar
Abstract
Human type II alveolar pneumonocytes were grown as monolayers derived from a clone or as organotypic cultures of fetal lung. Type II cells in these cultures retained in their cytoplasm multilamellar bodies which were morphologically identical to similar organelles present in type II cells of intact human fetal and adult lung. A number of respiratory viruses infected the cells and produced a cytopathic effect in the cultures. Viral components were detected in some infected cells. Adenovirus type 3, human coronavirus 229E and rhinovirus types 2 and 9 produced new infectious virus but influenza A and parainfluenza 3 virus apparently did not.