PROBABLE CLONAL ORIGIN OF ACUTE MYELOBLASTIC-LEUKEMIA FOLLOWING RADIATION AND CHEMOTHERAPY OF COLON CANCER

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 52  (4) , 659-663
Abstract
A 64 yr old female developed acute myeloblastic leukemia following radiation and drug therapy for colon carcinoma. The patient was heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD) and displayed types A and B isoenzymes in nonhematopoietic tissue. Only type B G-6-PD was observed in peripheral blood white cells. A karyotypic abnormality was found in peripheral blood and marrow cells but not in skin fibroblasts. The data are consistent with a clonal origin of this leukemia.

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