RENAL EXCRETION OF SYNTHETIC ARGININE-VASOPRESSIN INJECTED INTO DOGS

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Abstract
The renal excretion of antidiuretic activity was measured in 2 trained, hydrated dogs after injection of synthetic arginine-vasopressin in doses ranging from 4- 50 mU/kg. An average of 12% of the antidiuretic activity of the injected doses appeared in the urine. This percentage was independent of the dose over the range studied. The present findings support the hypothesis that arginine-vasopressin in the dog is excreted by the kidneys mainly by glomerular filtration.

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