Studies on Active and Passive Immunity in "Q" Fever Infected and Immunized Guinea Pigs

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Abstract
Vaccines were prepared from the spleens and livers of mice and the spleens of guinea pigs inoculated with higher titer "Q" fever infected yolk sac suspensions. Vaccines prepared from 21/2% suspensions of such infected tissue immunized guinea pigs against 10,000 to 10,000,000 minimal infective doses. Hyperimmune sera were produced in guinea pigs and rabbits by the inoculation of killed cultures followed by live cultures. These agglutinated suspensions of "Q" fever rickettsiae were in dilutions up to 110240. Tests for passive immunity in guinea pigs were made, using hyperimmune sera and convalescent sera from guinea pigs. Hyperimmune sera neutralized up to 500,000 minimal infective doses and convalescent serum neutralized 500 minimal infective doses.