Preparation of Metabolites of Spironolactone by Microbial Oxygenation
Open Access
- 1 January 1973
- journal article
- research article
- Published by American Society for Microbiology in Applied Microbiology
- Vol. 25 (4) , 647-649
- https://doi.org/10.1128/aem.25.4.647-649.1973
Abstract
It has been postulated that 3-(3-oxo-7α-methylthio-4-androsten-17α-yl)propionic acid γ-lactone (I) is a key intermediate in the metabolism of the anti-aldosterone agent, spironolactone (3-[3-oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-yl] propionic acid γ-lactone). In the present study it was found that microbial oxygenation of I by Chaetomium cochloides QM 624 gave three metabolites which retained sulfur in their molecules and were found to be identical to the human metabolites of spironolactone.Keywords
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