Ethanol Increases Hepatic Smooth Endoplasmic Reticulum and Drug-Metabolizing Enzymes
- 29 March 1968
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 159 (3822) , 1469-1470
- https://doi.org/10.1126/science.159.3822.1469
Abstract
Rats were fed ethanol for 2 weeks along with diets either adequate or deficient in protein and choline, the latter intake being similar to that of many alcoholics. Hepatic lipids, smooth endoplasmic reticulum, and the activities of drug-metabolizing enzymes (aniline hydroxylase and nitroreductase) were increased with the adequate diet but more so with the deficient one. These results may explain the increased tolerance by alcoholics of drugs such as sedatives.This publication has 5 references indexed in Scilit:
- Fatty Liver in the Rat after Prolonged Intake of Ethanol with a Nutritionally Adequate New Liquid DietJournal of Nutrition, 1967
- Metabolic Derangement Induced by AlcoholAnnual Review of Medicine, 1967
- Activation and inhibition of microsomal hydroxylation by ethyl isocyanideBiochemical and Biophysical Research Communications, 1966
- Wechselwirkungen zwischen Alkohol und ArzneimittelnDeutsche Medizinische Wochenschrift (1946), 1966
- Biochemistry of Drug Oxidation and Reduction by Enzymes in Hepatic Endoplasmic ReticulumPublished by Elsevier ,1966