CASEIN-INDUCED EXPERIMENTAL AMYLOIDOSIS .6. PATHOGENIC ROLE FOR B-CELLS IN MURINE MODEL

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 31  (3) , 443-453
Abstract
The relationship between cellular (B[bone marrow-derived]-cell) responses and the development of casein-induced amyloidosis was explored. B-cell abnormalities are more pronounced in amyloid susceptible CBA/J than in amyloid resistant A/J mice; these include increased mitogen responses to SIII [pneumococcal polysaccharide], poly IC and DxS [dextran sulfate], and enhanced primary immune responses to T[thymus-derived]-independent antigens. CBA/J amyloid spleen cell suspensions appear to be enriched with antibody dependent killer cells and precursors of antibody-forming cells; these abnormalities are not seen in casein treated A/J mice. This hitherto unrecognized proliferation of immunoblasts in casein-treated CBA/J animals raises the possibility that B cell-macrophage interaction may play an important role in the pathogenesis of amyloid disease.