Pleomorphic Carcinoma of the Larynx

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Abstract
THIS unusual and rare lesion has been called squamous cell carcinoma with sarcoma-like stroma, carcinosarcoma, pseudosarcoma, etc. It has interesting clinical, morphologic and histopathologic facets. The primary lesion is a squamous cell or epidermoid carcinoma, but this is often overshadowed or completely missed because of a stroma which suggests anything from high grade spindle cell carcinoma to a variety of sarcoma types, or just a fibroblastic proliferation associated with a chronic inflammatory cell reaction. The source of the spindle cell component, stromal or epithelial, is argued. Present consensus is that the source is epithelial and that the various tumor cell forms encountered in the stroma all stem from the squamous epithelium: a truly pleomorphic phenomenon. Our cases below demonstrate this apparent transformation from squamous to spindle cell forms. Carcinosarcoma and collision tumor warrant differential discussion. The term pseudosarcoma deserves mention. Paradoxically, the histopathology implies a high degree of malignancy, yet

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