Thyroid Therapy of Myxedema

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Abstract
Patients with hypothyroidism were treated with 60 mg thyroid U.S.P. or thyroglobulin, 0.1 mg sodium 1-thyroxine and 0.025 mg 1-triiodothyronine in daily oral doses sufficient and roughly equal in effectiveness to relieve clinical manifestations of the hypothyroidism. The PBI was subnormal with thyroglobulin, low to mid-normal with thyroid U.S.P., high normal to supernormal with thyroxine, and almost nil with triiodothyronine. An attempt has been made to explain these differences on the basis of difference in absorbability and affinity for serum proteins of thyroxine and triiodothyronine. Evidence has been presented that triiodothyronine provides a substantial proportion of the effect of endogenous thyroid secretion and of ingested thyroid in man.

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