Recurrence after a surgically induced remission

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Abstract
In Dec. 1976, an 18 yr old woman had symptoms typical of Cushing''s syndrome. Laboratory evaluations and roentgenograms documented pituitary-dependent Cushing''s disease in a patient with a pituitary microadenoma. In May 1977, she underwent transsphenoidal pituitary exploration. A 2 mm pituitary microadenoma was removed. The patient improved, and laboratory evaluation documented remission of the disease. In June 1978, she again complained of symptoms compatible with Cushing''s disease. Laboratory evaluation confirmed a pituitary-dependent hypercortisonism. This case report marks the first recurrence of Cushing''s disease in a patient previously cured by transsphenoidal resection of a pituitary tumor.