Chemical structure, reactivity, and carcinogenicity of halohydrocarbons.
- 1 December 1977
- journal article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 21, 17-23
- https://doi.org/10.1289/ehp.772117
Abstract
This review summarizes studies concerning the covalent binding of [14C]TCE to rat liver microsomal protein and exogenous DNA, in vitro, the enhancement of this binding by inducers of mixed-function oxidases, and inhibition of binding by inhibitors of these enzymes. Furthermore, recent studies on this type of binding in various strains of mice and rats of both sexes and using microsomal preparations from various organs are briefly reviewed. Other work reviewed here concerns the synthesis of TCE epoxide and its reaction with nucleophiles since it is believed that TCE epoxide is the activated carcinogenic intermediate of TCE. The utility of structural prognostication of carcinogenic activity and the importance of considering possible metabolic pathways for other chlorinated olefins is also discussed.Keywords
This publication has 27 references indexed in Scilit:
- Recent findings on the carcinogenicity of chlorinated olefins.Environmental Health Perspectives, 1977
- Alkylation of DNA and proteins in mice exposed to vinyl chlorideBiochemical and Biophysical Research Communications, 1977
- Studies on the metabolism of vinyl chloride.Environmental Health Perspectives, 1976
- Mutagenicity and metabolism of vinyl chloride and related compounds.Environmental Health Perspectives, 1976
- Proceedings of the WHO-NIEHS conference on potential environmental health hazards from technological developments in rubber and plastics industries. Research Triangle Park, N.C., March 1-3, 1976: Introductory statement.Environmental Health Perspectives, 1976
- The reaction of 4‐(p‐nitrobenzyl)pyridine with some electrophilesJournal of Heterocyclic Chemistry, 1976
- METHODOLOGIES FOR RISK ASSESSMENT IN OCCUPATIONAL CARCINOGENESISAnnals of the New York Academy of Sciences, 1976
- ON THE POSSIBLE MECHANISM OF CARCINOGENIC ACTION OF VINYL CHLORIDEAnnals of the New York Academy of Sciences, 1975
- CARCINOGENICITY BIOASSAYS OF VINYL CHLORIDE: CURRENT RESULTSAnnals of the New York Academy of Sciences, 1975
- ACKNOWLEDGMENTSAnnals of the New York Academy of Sciences, 1975