Plasma secretin concentration in man: effect of intraduodenal glucose, fat, amino acids, ethanol, HCI, or ingestion of a meal

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Abstract
The effect of infusing isotonic saline, isotonic and hypertonic glucose, fat emulsion, amino acids, ethanol and HCl into the duodenum on the plasma concentration of immunoreactive secretin was studied in 7 normal subjects. Only HCl showed any effect. After acidification of the duodenum with HCl, a significant rise in plasma secretin concentration was observed from 1.3 .+-. 0.4 pmol .times. 1-1 (mean .+-. SEM) to a peak value of 13.0 .+-. 1.2 pmol .times. 1-1 after 5 min. The concentration returned to the basal level within 15 min. In 8 other normal subjects the plasma secretin concentration was measured after the ingestion of a protein-rich meal. No significant changes were observed during the 2 h postprandial period.