Haemodynamic effects of isopropylnoradrenaline sulphate (isoprenaline) following aortic valve homograft replacement.
Open Access
- 1 January 1968
- Vol. 30 (1) , 38-43
- https://doi.org/10.1136/hrt.30.1.38
Abstract
Increases in cardiac output were directly related to heart rate and inversely related to the control heart rate; the stroke volume generally remained constant. These changes were associated with a fall in total peripheral resistance, arteriovenous O2 difference, and left and right atrial pressures, a rise in venous O2 content and left ventricular minute work, and no change in the left ventricular stroke work and arterial blood pressure. Isoprenaline effectively lowered the pulmonary vascular resistance when raised. The administration of higher doses frequently resulted in arrhythmias; the appearance of nodal rhythm or ectoplc beats caused a fall in cardiac output desplte the increased isoprenaline dosage. The circulatory effects of isoprenaline following homograft replacement of the aortic valve are predominantly chronotroplc and weakly inotroplc.This publication has 14 references indexed in Scilit:
- Circulatory Changes resulting from increasing the Venous Filling Pressure by Transfusion following Aortic Valve Homograft ReplacementCardiovascular Research, 1967
- Stroke Volume and Peripheral Resistance during Infusion of Isoproterenol at a Constant Fixed Heart RateCirculation, 1965
- Studies on Cardiac Dimensions in Intact, Unanesthetized ManCirculation, 1964
- Adrenergic Receptors Within the Cardiovascular SystemCirculation, 1963
- Changes in Pulmonary Hemodynamics Produced by Isoproterenol Infusion in Emphysematous PatientsCirculation, 1963
- Differential hemodynamic effects of isoproterenol on mitral stenosis and left ventricular diseasesAmerican Heart Journal, 1963
- The hemodynamic effects of isoproterenol on pulmonary hypertension in manAmerican Heart Journal, 1963
- Effects of posture, upright exercise, and myocardial stimulation on cardiac output in patients with diseases affecting diastolic filling and effective systolic ejection of the left ventricleAmerican Heart Journal, 1961
- Cardiovascular effects of isoproterenol in normal subjects and subjects with congestive heart failureAmerican Heart Journal, 1960
- Catheter Replacement of the Needle in Percutaneous Arteriography: A new techniqueActa Radiologica, 1953