METABOLISM, TOXICITY AND MANNER OF ACTION OF GOLD COMPOUNDS USED IN THE TREATMENT OF ARTHRITIS. I. HUMAN PLASMA AND SYNOVIAL FLUID CONCENTRATION AND URINARY EXCRETION OF GOLD DURING AND FOLLOWING TREATMENT WITH GOLD SODIUM THIOMALATE, GOLD SODIUM THIOSULFATE, AND COLLOIDAL GOLD SULFIDE

Open Access
Publisher Website
Google Scholar
Abstract
AuNa thiomalate and AuNa thiosulfate injected intramusc. in equivalent amts. of Au resulted in similar plasma Au concs. and urinary excretion of gold; the plasma and urine Au varied with the size of the weekly dose but was not directly proportional to it. When colloidal Au2S3 was administered either orally or intramusc, the plasma and urine Au varied greatly in different patients; some absorbed the Au but most had very low plasma Au concs. and excreted little Au in the urine. In some subjects no Au was found in plasma or urine after colloidal Au2S3 was given in large amts. Au was eliminated in the urine very slowly. Blood and urine contained Au in significant amts. for a long time after adm.; the length of time corresponded approx. to the size of the weekly dose. Toxic reactions were much more frequent in subjects receiving large weekly injns. of AuNa thiomalate or AuNa thiosulfate. Many toxic reactions resulted from retention of Au in amts. sufficient to poison the patient and could be prevented by giving smaller doses. Therapeutic results were quite as good as with the conventional larger doses.

This publication has 0 references indexed in Scilit: