Botulism and Guanidine
- 25 April 1968
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 278 (17) , 931-933
- https://doi.org/10.1056/nejm196804252781704
Abstract
A 57-year-old woman with a fatal disease, presumably botulism, was treated intermittently with guanidine hydrochloride over a 20-day period. Guanidine was given because it enhances the release of acetylcholine at the neuromuscular junction. During treatment, ptosis and extraocular palsies were relieved, strength in proximal muscles improved, and muscle-action potentials increased from 1 to 2 mV to 4 to 7 mV.This publication has 12 references indexed in Scilit:
- The botulinal, tetanal, and enterostaphylococcal toxins: A reviewClinical Pharmacology & Therapeutics, 1967
- Motor responses of the urinary bladder and skeletal muscle in Botulinum intoxicated ratsThe Journal of Physiology, 1967
- Effect of guanidinium salts on the toxicity of botulinum toxinBiochimica et Biophysica Acta (BBA) - General Subjects, 1964
- LOCALIZATION OF FERRITIN-LABELLED BOTULINUS TOXIN IN THE NEUROMUSCULAR JUNCTION OF THE MOUSEJournal of Neuropathology and Experimental Neurology, 1962
- The Most Poisonous PoisonScience, 1959
- BACTERIAL NEUROTOXINSThe Lancet Healthy Longevity, 1958
- The action of botulinum toxin on motor‐nerve filamentsThe Journal of Physiology, 1954
- The action of botulinum toxin on the neuro‐muscular junctionThe Journal of Physiology, 1949
- PHYSIOLOGY OF BOTULINUS TOXINArchives of Neurology & Psychiatry, 1947
- USE OF GUANIDINE HYDROCHLORIDE IN TREATMENT OF MYASTHENIA GRAVISJAMA, 1939