Melanocyte-Stimulating Hormone-Release Inhibiting Hormone as an Antidepressant
- 1 January 1974
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 30 (1) , 63-65
- https://doi.org/10.1001/archpsyc.1974.01760070047007
Abstract
The melanocyte-stimulating hormone (MSH)-release inhibiting hormone, prolyl-leucyl-glycinamide (MRIH-I), is a hypothalamic hormone active in animal systems used as models of depression. In a double-blind, clinical trial, four of five patients with mental depression, who received 60 mg of MRIH-I for each of six consecutive days, experienced marked improvement for their symptoms within. two to three days. The preliminary nature of these findings, however, is emphasized by the improvement in two of four patients receiving a placebo and only two of five patients receiving 150 mg of MRIH-I.Keywords
This publication has 3 references indexed in Scilit:
- Regulation of Formation and Proposed Structure of the Factor Inhibiting the Release of Melanocyte-Stimulating HormoneProceedings of the National Academy of Sciences, 1971
- Isolation and structure of hypothalamic MSH release-inhibiting hormoneBiochemical and Biophysical Research Communications, 1971
- A RATING SCALE FOR DEPRESSIONJournal of Neurology, Neurosurgery & Psychiatry, 1960