An Experimental Model for the Study of Hepatic Transport and Metabolism of Toxic Compounds
- 1 January 1979
- book chapter
- Published by Springer Nature
- No. 2,p. 339-343
- https://doi.org/10.1007/978-3-642-67265-1_33
Abstract
The usefulness of isolated liver cells for the study of hepatocellular transport and metabolism is demonstrated, using 1-naphthol and 2,2′-dichlorobiphenyl as model compounds. More than 60% of both substances is rapidly taken up by the cells. Naphthol is conjugated with sulphate and with glucuronic acid. These conjugates are released from the cells. Conjugation of dichlorobiphenyl and release of the conjugates is about 25 times slower than that of naphthol.Keywords
This publication has 10 references indexed in Scilit:
- Metabolism of 14C‐Antipyrine in Suspensions of Isolated Rat Liver CellsActa Pharmacologica et Toxicologica, 1977
- Excretion of Taurocholate from Isolated HepatocytesEuropean Journal of Biochemistry, 1976
- Metabolism of naphthalene to naphthalene dihydrodiol glucuronide in isolated hepatocytes and in liver microsomesBiochemical Pharmacology, 1976
- Oxidative and Conjugative Metabolism of p–Nitroanisole and p–Nitrophenol in Isolated Rat Liver CellsActa Pharmacologica et Toxicologica, 1976
- Uptake of Bromosulfophthalein byIsolated Liver CellsEuropean Journal of Biochemistry, 1976
- Uptake of Taurocholic Acid into Isolated Rat‐Liver CellsEuropean Journal of Biochemistry, 1975
- Criteria of Viability of Isolated Liver CellsHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1975
- UDP glucuronyltransferase activity in isolated perfused rat liverNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1973
- HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLSThe Journal of cell biology, 1969
- Biochemical studies of toxic agents. 3. The isolation of 1- and 2-naphthylsulphuric acid and 1- and 2-naphthylglucuronide from the urine of rats dosed with 1- and 2-naphtholBiochemical Journal, 1951