Ovulatory changes in the wall at the apex of the human Graafian follicle

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Abstract
The apical wall was ultrastructurally studied in 16 human follicles at various stages of development. In the theca externa and tunica albuginea at the apex of growing follicles, fibroblasts with little cytoplasm and abundant collagen fibers were observed. In the mature follicles, the fibroblastic cytoplasm was well developed, rich in lysosome-like granules and contained peripheral multivesicular structures. Intercellular collagen fibers were sparse. The collagen fibers are evidently digested by the content of lysosomal granules and multivesicular structures, thus aiding follicular rupture.

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