Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus
- 7 May 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 264 (1) , 29-32
- https://doi.org/10.1016/0014-5793(90)80756-9
Abstract
The three intramolecular disulfide linkages of geographutoxin I, a peptidic neurotoxin isolated from the venom of the marine snail Conus geographus, were examined by a novel method for determination of the positions of disulfide linkages in peptides [(1989) Bull. Chem. Soc. Jp. 62, 1986–1994]. The disulfide bridges were found to be between Cys3 and Cys15, Cys4 and Cys20, and Cys10 and Cys21, indicating that geographutoxin I has a rigid conformation consisting of three loops stabilized by these three disulfide linkages.Keywords
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