ASPECTS OF CARBOHYDRATE METABOLISM IN NEWBORN INFANTS OF DIABETIC MOTHERS. V

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Abstract
In 14 infants of diabetic and 14 infants of normal mothers an acute iv glucose load was given 3 hours after birth, and the plasma glucose was determined during the subsequent 150 min. Two patterns of decrease in plasma glucose concentration were seen. In 8 infants of normal and 6 of diabetic mothers the minimum plasma glucose level – 37 and 39 mg/100 ml – was observed 110 and 90 min respectively after the injection of glucose. All these infants exhibited a significant increase in plasma glucose concentration during the next 40–50 min (rebound phenomenon). In the remaining 6 infants of normal and 8 of diabetic mothers, the lowest plasma glucose level – 65 and 54 mg/100 ml – occurred during the period 120–150 min after the injection of glucose, and the glucose concentration fell more slowly and continued to decrease throughout the observation period. The results indicate that counter-regulatory mechanisms against hypoglycaemia are operative in newborn infants of normal as well as of diabetic mothers. Thus, there is hardly any reason to fear persistent hypoglycaemia following acute glucose load in newborn infants.

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