Transformation of arachidonic acid into monohydroxy‐eicosatetraenoic acids by mouse peritoneal macrophages
- 1 July 1981
- Vol. 16 (7) , 518-524
- https://doi.org/10.1007/bf02535050
Abstract
Mouse peritoneal macrophages synthesize 6 monohydroxylated eicosatetraenoic acids when incubated with exogenous arachidonic acid. These compounds were identified by chromatographic techniques (high pressure liquid chromatography and high efficiency glass capillary column gas chromatography and mass spectrometry. The chromatographic and spectrometric data are presented. These results show that peritoneal macrophages constitute one of the best systems to study in evaluating the metabolism of oxygenated products of arachidonic acid.This publication has 16 references indexed in Scilit:
- Complete profiling of some eicosanoids using glass capillary gas chromatography with flame ionization detection: Application to biological samplesAnalytical Biochemistry, 1980
- Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils.The Journal of Experimental Medicine, 1979
- The autoxidation of arachidonic acid: Formation of the proposed SRS-A intermediateBiochemical and Biophysical Research Communications, 1979
- Transformation of arachidonic acid into 12-hydroxy-5,8,10,14-eicosatetraenoic acid by mouse peritoneal macrophagesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1979
- Une nouvelle technique de fabrication de colonnes capillaires de verre, utilisant des chlorosilanes polymerises. Application a l'analyse des steroides et des prostaglandines.Tetrahedron Letters, 1976
- Control of lymphokine secretion by prostaglandinsNature, 1976
- On the formation of thromboxane B2 and 12L-hydroxy-5, 8,10,14-eicosatetraenoic acid (12 ho-20:4) in tissues from the guinea pigBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1976
- Macrophages on intrauterine contraceptive devices produce prostaglandinsNature, 1975
- Arachidonate lipoxygenase in blood plateletsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1975
- Prostaglandin endoperoxides VII. Novel transformations of arachidonic acid in guinea pig lungBiochemical and Biophysical Research Communications, 1974