The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptophan pyrrolase and their resemblance to those of ethanol
- 1 November 1973
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 135 (3) , 555-557
- https://doi.org/10.1042/bj1350555
Abstract
Chronic phenobarbitone administration inhibits the apo-(tryptophan pyrrolase) activity in homogenates of rat liver and subsequent withdrawal enhances the enzyme activity by 2.5-fold. Similar effects have been previously produced by chronic ethanol administration and withdrawal, but, whereas NADH may cause the ethanol inhibition, that by phenobarbitone may be mediated by NADPH.Keywords
This publication has 8 references indexed in Scilit:
- The mechanism of inhibition of rat liver tryptophan pyrrolase activity by 4-hydroxypyrazolo[3,4-d]pyrimidine (allopurinol)Biochemical Journal, 1973
- The relationship between δ-aminolaevulinate synthetase induction and the concentrations of cytochrome P-450 and catalase in rat liverBiochemical Journal, 1972
- A comparison of mouse and rat liver enzymes and their response to treatment with various compoundsBiochemical Pharmacology, 1972
- Changes in liver tryptophan and tryptophan pyrrolase activity after administration of salicylate and tryptophan to the ratBiochemical Pharmacology, 1972
- The effects of salicylate on the activity of rat liver tryptophan pyrrolase in vitro and in vivoBiochemical Journal, 1971
- Effect of chronic intake of ethanol on pyridine nucleotide levels in rat liver and kidneyCanadian Journal of Physiology and Pharmacology, 1970
- FEEDBACK CONTROL OF RAT LIVER TRYPTOPHAN PYRROLASE .I. END PRODUCT INHIBITION OF TRYPTOPHAN PYRROLASE ACTIVITY1967
- A Microsomal Iron-Porphyrin Activator of Rat Liver Tryptophan PyrrolaseJournal of Biological Chemistry, 1961