Measurement of Plasma Digoxin Concentration by Radioimmunoassay
- 22 August 1970
- Vol. 3 (5720) , 427-428
- https://doi.org/10.1136/bmj.3.5720.427
Abstract
A rapid, sensitive, and precise method for measuring the plasma digoxin concentration has been developed with the radioimmunoassay technique. Seventy patients receiving digoxin were shown to have plasma digoxin concentrations between 0·4 and 5 ng./ml. Preliminary studies show that though there is a positive correlation between total daily dose and the plasma digoxin concentration, the relationship is not close, and a relatively wide range of plasma digoxin concentrations appear to be consistent with effective digitalization.Keywords
This publication has 11 references indexed in Scilit:
- Determination of Therapeutic and Toxic Serum Digoxin Concentrations by RadioimmunoassayNew England Journal of Medicine, 1969
- Plasma and myocardial digoxin concentrations in patients on oral therapy.Heart, 1969
- A simple liquid scintillator solution for assay of tritium in plasma or serumThe International Journal of Applied Radiation and Isotopes, 1969
- Measurement of Digoxin in Plasma and its use in Diagnosis of Digoxin IntoxicationBMJ, 1969
- The measurement of digitoxin in human serum by radioimmunoassayJournal of Clinical Investigation, 1968
- The Distribution and Concentration of Tritiated Digoxin in Human TissuesAnnals of Internal Medicine, 1967
- Administration of Tritiated Digoxin with and without a Loading DoseCirculation, 1966
- Double isotope dilution derivative assay of digitoxin in plasma, urine, and stool of patients maintained on the drug.Journal of Clinical Investigation, 1966
- AN IMPROVED METHOD FOR MEASURING PLASMA AND TISSUE CONCENTRATIONS OF DIGITALIS GLYCOSIDES1966
- Coated Charcoal Immunoassay of InsulinJournal of Clinical Endocrinology & Metabolism, 1965