Studies of Anabolic Steroids: V. Effect of Prolonged Oxandrolone Administration on Growth in Children and Adolescents With Uncomplicated Short Stature

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Abstract
Patients (130) with uncomplicated short stature (4-17 yr of age) were treated with oxandrolone, 0.25 mg/kg per day, for to 4 yr. Oxandrolone therapy resulted in a 2-fold increase in mean growth velocity in the first 6-mo. of therapy and was an effective growth stimulant for the full 4-yr period. There was no overall adverse effect of oxandrolone on post-treatment mean growth velocity or on skeletal maturation relative to height gain. There were 37 patients with greater increase in height age than bone age and 22 patients with greater increase in bone age than height age. Assessment of the contribution of oxandrolone therapy to the latter group is difficult because of inadequate methodology and the wide variation in individual growth patterns. Oxandrolone is probably useful in the prolonged treatment of uncomplicated short stature and is probably not associated with undesirable acceleration of skeletal maturation.

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