Effect of Chronic Ethanol Intoxication on Liver Lipid Content of Rats.

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Abstract
Chronic alcohol intoxication was produced in rats by tube feeding diets in which ethanol was isocalorically substituted for some of the carbohydrate in the control diet. The intoxicated rats uniformly showed an increase of about 36% in liver fat within approximately 30 days. This occurred on diets that were adequate for the maintenance of good growth and normal liver lipid concentrations in non-alcoholic animals. Large supplements of the lipotropic vitamins B12 and choline, protected against this fatty infiltration of the liver. Chronically intoxicated animals grew at a significantly lower rate than did isocalorically fed non-alcoholic controls on the same diet.

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