Using Relative Cerebral Blood Flow and Volume to Evaluate the Histopathologic Grade of Cerebral Gliomas: Preliminary Results

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Abstract
OBJECTIVE. Relative cerebral blood flow has rarely been studied as part of the preoperative assessment of tumor grade, although relative cerebral blood volume is known to be useful for this assessment. The purpose of our study was to determine the usefulness of relative cerebral blood flow in assessing the histopathologic grade of cerebral gliomas.SUBJECTS AND METHODS. MR imaging was performed in 17 patients with proven cerebral gliomas (11 high-grade gliomas and six low-grade gliomas), using a first-pass gadopentetate dimeglumine—enhanced T2-weighted echoplanar perfusion sequence. The perfusion data were deconvoluted with an arterial input function, using singular value decomposition to obtain a color map of relative cerebral blood volume and flow; the relative cerebral blood volume and flow ratios were expressed relative to values measured in the contralateral white matter. The Wilcoxon's rank sum test was performed to test the difference between the mean of the relative cerebral blood volume (or flow) ...