DISTRIBUTION AND EXCRETION OF 7-N-(PARA-HYDROXYPHENYL)-MITOMYCIN-C IN NORMAL MICE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 73  (4) , 675-680
Abstract
Tissue distribution, excretion and stability of [the antineoplastic drug] 7-N-(p-hydroxyphenyl)-mitomycin C (M-83) in normal mice were compared with those of [the antineoplastic drug] mitomycin C (MMC) by microbiological assay. M-83 was more rapidly inactivated by mouse liver homogenate in vitro than MMC. MMC could not be detected by TLC-bioautography in the reaction mixture of M-83 incubated with mouse liver homogenate, or in the mouse urine. Both M-83 and MMC exhibited biphasic serum elimination characteristics after i.v. bolus injection. When these compounds were administered at their approximate LD50 (M-83, 20 mg/kg; MMC, 8 mg/kg) i.v. into mice, their half-lives were 17.9 and 19.8 min, respectively. However, the half-life of M-83 (10.2 mg/kg) after i.v. bolus injection was 7.5 min and was shorter than that of MMC (8 mg/kg) at the molar equivalent dose. In i.p. administration of an approximate LD50, M-83 and MMC exhibited similar drug absorption and elimination patterns. When both compounds were administered i.v. at the approximate LD50, the 24-h urinary recoveries of unchanged M-83 and MMC were 2.85 and 19.26%, respectively. The distribution of M-83 in various tissues was similar to that of MMC.

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