Nitazoxanide Kills Replicating and Nonreplicating Mycobacterium tuberculosis and Evades Resistance
- 8 September 2009
- journal article
- letter
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 52 (19) , 5789-5792
- https://doi.org/10.1021/jm9010719
Abstract
We report here that nitazoxanide (NTZ) and its active metabolite kill replicating and nonreplicating M. tuberculosis at low μg/mL levels. NTZ appears to evade resistance, as we were unable to recover resistant colonies, using up to 1012 colony forming units. Therefore, NTZ is a novel lead compound that kills replicating and nonreplicating M. tuberculosis by a novel mechanism of action, which appears to bypass the development of resistance.Keywords
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