Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-kB activity

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Abstract
Nuclear factor kB (NF-kB) is an important stress-induced transcription factor in many cell types, including hepatocytes. Previous studies have shown that reactive oxygen species, including hydrogen peroxide, are potent activators of NF-kB. Peroxisome proliferators are a group of rodent chemical carcinogens that have been proposed to act by increasing reactive oxygen in the liver. These results led us to consider whether peroxisome proliferators would increase NF-kB activity in the liver. Here we demonstrate that rats fed diets containing the peroxisome proliferator ciprofibrate exhibit increased hepatic NF-kB DNA-binding activity. This observation suggests that NF-kB may contribute, in part, to peroxisome proliferator-mediated changes in the liver.

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