SOME ASPECTS OF BILIARY-SECRETION IN 4 SPECIES OF PRIMATES (P-MANDRILLUS, P-PAPIO, E-PATAS AND M-MULATTA)

  • 1 January 1977
    • journal article
    • research article
    • Vol. 33  (1) , 31-35
Abstract
Effect of several factors on flow and composition of bile of 4 species of Primates was studied. Flow of bile widely varied. The smallest flow was found in Erythrocebus patas and the greatest in Papio mandrillus; P. papio and Macaca mulatta flows were intermediate. Cholic acid concentration in basal bile was small. Na+, K+ and Cl- were found in concentration close to its plasmatic values. In all 4 species, interruption of enterohepatic circulation of bile salt, induced a clear decrease in basal flow. Secretin injection (1 units(u)/kg) induced flow increases in P. mandrillus. In M. mulatta and E. patas relationship between logarithm of secretin doses and biliary responses seems to occur. Cholecystokinin-Pancreozymin (2 U/kg) produced in P. papio spectacular increases of flow and bile salts concentration with concomitant chloride decreases. Vagal stimulation gave no clear results, although vagal section and use of parasympathicolic drugs induced bile flow decreases that show a possible tonic vagal action on extrahepatic biliary tree.

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