Effects of glucose on phosphorylase and glycogen synthase in hepatocytes from diabetic rats
- 15 March 1983
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 210 (3) , 783-787
- https://doi.org/10.1042/bj2100783
Abstract
The effects of glucose on phosphorylase and glycogen synthase were investigated in hepatocytes isolated from acutely (40 h) and chronically (90 h) alloxan-diabetic rats. The glucose-induced inactivation of phoshorylase proceeded normally in all conditions. The ensuing activation of glycogen synthase was slightly blunted in acute diabetes, but became virtually absent in 72 h diabetes of similar severity. In hepatocytes from rats with various degrees of chronic diabetes, the maximal activation of glycogen synthase (at 60 mM-glucose) was inversely correlated with the plasma glucose concentration.This publication has 18 references indexed in Scilit:
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