CHMP2B mutations are not a cause of dementia in Dutch patients with familial and sporadic frontotemporal dementia
- 22 November 2006
- journal article
- research article
- Published by Wiley in American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics
- Vol. 141B (8) , 944-946
- https://doi.org/10.1002/ajmg.b.30410
Abstract
Mutations in the CHMP2B gene have been recently identified in a large Danish pedigree with autosomal dominant frontotemporal dementia (FTD) linked to chromosome 3 (FTD3). We report the frequency of CHMP2B mutations in 162 FTD patients recruited from a large population‐based study of FTD carried out in The Netherlands. Our results suggest that mutations in CHMP2B are a rare cause of FTD as compared to MAPT mutations.Keywords
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