Acute effects of increased meat protein on urinary electrolytes and cyclic adenosine monophosphate and serum parathyroid hormone

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Abstract
The effect of a high meat protein diet on urinary electrolytes, cyclic AMP, and serum immunoassayable parathyroid hormone was studied in six subjects fed a high meat protein diet (1.5 to 2.0 g/kg) for 7 days. The diet produced minor decreases in serum calcium and phosphorus but increased endogenous creatinine clearance by about 20% (p < 0.02) and urinary calcium by about 80% (p < 0.01) without changing urinary sodium. Urinary calcium correlated (p < 0.01) with urinary sulfate (r = 0.60), ammonia (r = 0.72), and nitrogen (r = 0.60). Urinary cyclic AMP increased (p < 0.01) 14% while serum parathyroid hormone (measured by C-terminal assays) decreased (p < 0.05) by more than 30%. It was concluded 1) that this diet acutely altered renal handling of calcium at a site different from that of sodium, 2) that the excretion of acidic products of protein metabolism contributed to these changes, and 3) that parathyroid hormone secretion was not changed acutely.