A Drosophila Model of Mitochondrial DNA Replication: Proteins, Genes and Regulation
Open Access
- 1 August 2005
- journal article
- review article
- Published by Wiley in IUBMB Life
- Vol. 57 (8) , 555-561
- https://doi.org/10.1080/15216540500215572
Abstract
Mitochondrial biogenesis is a critical process in animal development, cellular homeostasis and aging. Mitochondrial DNA replication is an essential part of this process, and both nuclear and mitochondrial DNA mutations are found to result in mitochondrial dysfunction that leads to developmental defects and delays, aging and disease. Drosophila provides an amenable model system to study mitochondrial biogenesis in normal and disease states. This review provides an overview of current approaches to study the proteins involved in mitochondrial DNA replication, the genes that encode them and their regulation. It also presents a survey of cell and animal models under development to mimic the pathophysiology of human mitochondrial disorders. IUBMB Life, 57: 555‐561, 2005Keywords
This publication has 38 references indexed in Scilit:
- Energy biogenesis: one key for coordinating two genomesTrends in Genetics, 2005
- Discovery of a Major D-Loop Replication Origin Reveals Two Modes of Human mtDNA SynthesisScience, 2004
- DNA Polymerase γ, The Mitochondrial ReplicaseAnnual Review of Biochemistry, 2004
- Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomesNature Reviews Genetics, 2004
- Response: The mitochondrial DNA replication bubble has not burstTrends in Biochemical Sciences, 2003
- The mitochondrial DNA replication bubble has not burstTrends in Biochemical Sciences, 2003
- The mitochondrial theory of aging: dead or alive?Aging Cell, 2003
- Drosophila Mitochondrial Transcription Factor A: Characterization of Its cDNA and Expression Pattern during DevelopmentBiochemical and Biophysical Research Communications, 2001
- Overexpression of the catalytic subunit of DNA polymerase γ results in depletion of mitochondrial DNA in Drosophila melanogasterMolecular Genetics and Genomics, 2000
- Vertebrate Mitochondrial DNA—A Circle of SurprisesExperimental Cell Research, 2000