High frequency of BRAF mutations in nevi
Top Cited Papers
- 25 November 2002
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 33 (1) , 19-20
- https://doi.org/10.1038/ng1054
Abstract
To evaluate the timing of mutations in BRAF (v-raf murine sarcoma viral oncogene homolog B1) during melanocytic neoplasia, we carried out mutation analysis on microdissected melanoma and nevi samples. We observed mutations resulting in the V599E amino-acid substitution in 41 of 60 (68%) melanoma metastases, 4 of 5 (80%) primary melanomas and, unexpectedly, in 63 of 77 (82%) nevi. These data suggest that mutational activation of the RAS/RAF/MAPK pathway in nevi is a critical step in the initiation of melanocytic neoplasia but alone is insufficient for melanoma tumorigenesis.Keywords
This publication has 4 references indexed in Scilit:
- Mutations of the BRAF gene in human cancerNature, 2002
- Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytesThe EMBO Journal, 2000
- The Regulation of Normal Melanocyte ProliferationPigment Cell Research, 2000
- Tissue microarrays for high-throughput molecular profiling of tumor specimensNature Medicine, 1998