Pentagastrin induced motility pattern in the human upper gastrointestinal tract is reversed by proglumide.
- 1 September 1984
- Vol. 25 (9) , 953-956
- https://doi.org/10.1136/gut.25.9.953
Abstract
The effects of pentagastrin and the putative gastrin antagonist proglumide on interdigestive motility of the upper small bowel were studied in a randomised double blind study in 10 healthy human volunteers. Intraluminal pressures were recorded manometrically in the duodenum and jejunum for five hours. Sixty minutes after starting a pentagastrin infusion (0.15 micrograms/kg/h) either placebo or proglumide was infused intravenously. Pentagastrin converted the normal interdigestive motility to irregular motor activity, while proglumide restored the periodic fasted pattern. We conclude that gastrin is a likely candidate involved in the conversion of the fasted to the fed motility pattern in the human upper gut.This publication has 21 references indexed in Scilit:
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