Aplastic anaemia and paroxysmal nocturnal haemoglobinuria: a study of the GPI‐anchored proteins on human platelets
- 1 June 1996
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 93 (3) , 586-589
- https://doi.org/10.1046/j.1365-2141.1996.d01-1684.x
Abstract
Twenty‐six consecutive patients with acquired aplastic anaemia (AA) and nine patients with de novo paroxysmal nocturnal haemoglobinuria (PNH) were included in this study. In these 35 patients a GPI‐anchored molecule defect at the platelet surface was investigated by flow‐cytometry. Platelets from eight out of the nine patients with de novo PNH were found to be deficient for the GPI‐anchored molecule CD55, CD58 and CD59. We also detected a GPI‐anchored molecule defect on monocytes, granulocytes, and erythrocytes in all patients with de novo PNH. Among the 26 AA patients, a GPI defect was detected on platelets in five patients. Interestingly, these five patients were also found to have a GPI‐anchored molecule defect on erythrocytes, whereas in 10 patients the GPI‐anchored molecule defect was only detected on monocyte and polymorphonuclear (PMN) cells.Keywords
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