Spontaneous Nephrosis, with Proteinuria, Hyperglobulinemia, and Hypercholesterolemia in the Rat.

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Abstract
Summary A form of spontaneous nephrosis characterized by proteinuria, hyperglobulinemia and hypercholesterolemia occurs in the Sprague-Dawley rat. Proteinuria exists at weaning, and microscopically observed changes appear at 60 days of age. Degree of proteinuria corresponds with severity of lesions, and both increase with age. In young rats, globulin is the chief protein component excreted in the urine. In older animals, the albumin fraction predominates. Serum globulin increases with age, but serum albumin shows little change. Hypercholesterolemia is observed in 640-day-old rats.

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