CYTOSTATIC ACTION OF 2-NITRONAPHTHOFURANS ON L1210 MURINE LEUKEMIA-CELLS IN SEMISOLID MEDIUM

  • 1 January 1981
    • journal article
    • research article
    • Vol. 68  (4) , 328-331
Abstract
The cytostatic effects of derivatives of 2-nitro-naphthofurans were determined in vitro on L1210 leukemia cells. A recently described new bio-assay (Discotest) was used, which consists in plating the cells in soft agarose and placing on top of the agarose layer a paper disc soaked with the compound to be tested. The halo of inhibition of colony formation which results from diffusion of the compound is proportional to the logarithm of the compound concentration. The most active derivatives were the 2-nitro-7-methoxy and 2-nitro-8-methoxy-naphtho[2,1-b] furans which are known to be highly bactericid and protozoocid.

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