Quantitative structure-activity relation of antimalarial and dihydrofolate reductase inhibition by quinazolines and 5-substituted benzyl-2,4-diaminopyrimidines

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Abstract
A quantitative structure-activity relationship (QSAR) for the inhibition of dihydrofolate reductase from Streptococcus faecium by quinazolines was formulated. This is compared with a QSAR for inhibition of Escherichia coli dihydrofolate reductase by 2,4-diamino-5-benzylpyrimidines. The QSAR for inhibition of bacterial enzyme is compared with QSAR for mammalian enzyme inhibition. A QSAR was also formulated for the antimalarial action of quinazolines against P. berghei in mice. The antimalarial QSAR is consistent with that of the in vitro bacterial study.

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