CHEMOTHERAPY OF MALIGNANT OVARIAN-TUMORS - THERAPEUTIC RESULTS OF IFOSFAMIDE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 33  (7) , 1071-1076
Abstract
The therapeutic results of ifosfamide on primary ovarian malignancies in 30 [human] cases treated at Kurume University Hospital [Kurume, Japan] from Sept. 1978-Dec. 1980 are reported. These cases were advanced or recurrent ones. Histologically, they consisted of serous cystadenocarcinoma in 22 cases, mucinous cystadenocarcinoma in 2, unclassified adenocarcinoma in 1 and malignant teratoma in 5. In the ifosfamide therapy, 2 g or 40 mg/kg per day were given i.v. for 5 consecutive days, and as observing the blood state and the general condition, it was repeated every 3 wk. The drug was given from 1 to 7 courses; the average was 3.3 courses. The effect was evaluated by Koyama-Saito''s criteria and Karnofsky''s criteria; the response was 48% in the adenocarcinoma group and 20% in the malignant teratoma by the former criteria; the rate was 64% and 20%, respectively, by the latter criteria. The main side effects were hemorrhagic cystitis, nausea and vomiting; myelotoxicity was low.

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