Maintenance of Elevated Blood Levels of Vitamin B 12 in Human Subjects

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Abstract
Serum levels of vitamin B12 were followed in two groups of healthy subjects given the vitamin intramuscularly either in the usual aqueous medium or as an oil-aluminum monostearate depot preparation. Following the administration of the vitamin in water, the blood levels rose and then subsided to levels existing before the test in eight to nine days. In both groups of subjects given the vitamin in the depot vehicle, the serum level of the vitamin at fifteen days was clearly above the levels before the test. One group, followed beyond this time, exhibited elevated levels through twenty-seven days with return to levels existing before the test at the thirtieth and thirty-fourth days. The groups given the vitamin in depot form exhibited serum levels elevated for four to five days above the twenty-four-hour level of the group given the aqueous preparation.

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