Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes

Top Cited Papers
Open Access
Publisher Website
Google Scholar
Abstract
Alzheimer disease (AD) is the most common form of dementia, affecting 5% of the population older than 65 years and 30% to 50% older than 80 years. Substantial progress was made identifying genes for rare forms of early-onset AD1-4 and this early success significantly contributed to biologic study of AD mechanisms and, more recently, multiple drug discovery approaches. Late-onset AD, the common form of the disease, has been more difficult to solve, with apolipoprotein E (APOE) being the only confirmed susceptibility locus.5 The combination of high-density genotyping methods, large well-characterized AD and control populations, and statistical methods to evaluate population stratification now provide the tools to identify additional genes contributing to AD risk.