Ultrastructural Alterations in Guinea Pig Mast Cells During Anaphylaxis
- 1 January 1971
- journal article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 40 (6) , 934-942
- https://doi.org/10.1159/000230475
Abstract
Guinea pigs passively sensitized with rabbit antisera were subjected to lethal anaphylaxis by an intravenous injection of antigen (bovine serum albumin or horse spleen ferritin). Specimens of lung were obtained for ultrastructural examination. During anaphylaxis pulmonary mast cells exhibit degranulative phenomena associated with intracellular fragmentation of cytoplasmic granule constituents. No apparent extracellular expulsion of granules was observed. It is suggested that histamine release under these circumstances occurs initially intracellularly, followed by amine liberation from the cell.Keywords
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