HEMODYNAMIC EFFECTS OF INTRA-ARTERIAL INJECTION OF DRUGS OF ABUSE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 79  (4) , 425-431
Abstract
Acute vascular insufficiency following intra-arterial injection of a variety of drugs was recognized for many years. The present study addresses the hypothesis that this vascular insufficiency may be due to vasospasm. Intra-arterial injections of logarithmic doses of drugs of abuse from the barbiturate, narcotic, non-narcotic analgesic and amphetamine groups were studied in baboons [Papio anubis]. All drugs except amphetamine produced significant increases in femoral flow. D-Amphetamine produced insignificant alteration in flow. Solid excipients, cornstarch and talcum powder when injected intra-arterially decreased flow, and vascular obstruction was shown angiographically. These data suggest that vasospasm is not a primary response of intra-arterial injection of drugs of abuse.

This publication has 0 references indexed in Scilit: