MTR discloses subtle changes in the normal-appearing tissue from relatives of patients with MS
- 22 January 2002
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 58 (2) , 317-320
- https://doi.org/10.1212/wnl.58.2.317
Abstract
The presence of normal-appearing brain tissue (NABT) changes was investigated in 30 first-degree relatives of patients with MS, using magnetization transfer ratio (MTR) histograms. When compared with controls, relatives of patients with familial (p = 0.01) and sporadic (p = 0.01) MS had lower NABT MTR histogram peak heights. This study suggests a reduction of truly normal NABT in asymptomatic relatives of patients with MS.Keywords
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