Pharmacotherapy and airway remodelling in asthma?
Open Access
- 1 February 2003
- Vol. 58 (2) , 163-174
- https://doi.org/10.1136/thorax.58.2.163
Abstract
Over the last few decades attention has largely focused on airway inflammation in asthma, but more recently it has been appreciated that there are important structural airway changes which have been grouped together under the term “airway remodelling”. It is only now that questions have been asked about the impact of treatment on these structural changes. This review examines the nature of these structural airway changes, the mechanisms of their generation, their potential consequences, and what is known about the ability of anti-asthma treatments to modulate these changes.Keywords
This publication has 98 references indexed in Scilit:
- β-adrenoceptor agonists interfere with glucocorticoid receptor DNA binding in rat lungEuropean Journal of Pharmacology: Molecular Pharmacology, 1995
- Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity.Journal of Clinical Investigation, 1994
- Theophylline in the management of asthma: time for reappraisal?European Respiratory Journal, 1994
- Reduction of budesonide after a year of increased use: A randomized controlled trial to evaluate whether improvements in airway responsiveness and clinical asthma are maintainedJournal of Allergy and Clinical Immunology, 1991
- Protection against allergen-induced asthma by salmeterolThe Lancet, 1990
- The Transforming Growth Factor-beta FamilyAnnual Review of Cell Biology, 1990
- Absence of Immunoreactive Vasoactive Intestinal Polypeptide in Tissue from the Lungs of Patients with AsthmaNew England Journal of Medicine, 1989
- Effect of therapy on bronchial hyperresponsiveness in the long-term management of asthmaClinical and Experimental Allergy, 1988
- Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthmaJournal of Allergy and Clinical Immunology, 1987
- Bronchoalveolar lavage in asthma: The effect of disodium cromoglycate (cromolyn) on leukocyte counts, immunoglobulins, and complementJournal of Allergy and Clinical Immunology, 1984