Treatment of Uremia by Lavage Through Intestinal Loops in Dogs

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Abstract
Four nephrectomized dogs were treated with lavage of isolated intestinal loops (made prior to nephrectomy). The animals survived for 7–13 days; death was caused by renoprival vascular disease. The rinsing fluids were hypotonic in electrolytes but made isotonic with glucose: 41 mEq/l. Na, 5.5 mEq/l. K, 5 mEq/l. Ca, 27.5 mEq/l. Cl, 24 mEq/l. HCO2, and 3.6% glucose. While a maximum of 4.5–12 gm urea could be removed during an 8-hour lavage, in these dogs this was not enough to keep blood urea within the normal range. Small amounts of Na and K were excreted through the intestinal loop: Na and K and water balance was not disturbed by the intestinal lavage. With the present rinsing fluid there was continuous loss of Cl. Submitted on July 29, 1955