High-volume haemofiltration in human septic shock
Top Cited Papers
- 18 May 2001
- journal article
- clinical trial
- Published by Springer Nature in Intensive Care Medicine
- Vol. 27 (6) , 978-986
- https://doi.org/10.1007/s001340100963
Abstract
Objective: To evaluate whether high volume haemofiltration improves haemodynamics and affects serum cytokine and complement concentrations in human septic shock. Design and setting: Randomized cross-over clinical trial in a tertiary intensive care unit. Patients: Eleven patients with septic shock and multi-organ failure. Interventions: Patients were assigned to either 8 h of high-volume haemofiltration (HVHF; 6 l/h) or 8 h of standard continuous veno-venous haemofiltration (CVVH; 1 l/h) in random order. Measurements and main results: We measured changes in haemodynamic variables, dose of norepinephrine required to maintain a mean arterial pressure greater than 70 mmHg and plasma concentrations of complement anaphylatoxins and several cytokines. An 8-h period of HVHF was associated with a greater reduction in norepinephrine requirements than a similar period of CVVH (median reduction: 10.5 vs. 1.0 µg/min; p=0.01; median percentage reduction: 68 vs. 7%; p=0.02). Both therapies were associated with a temporary reduction (ppConclusions: HVHF decreases vasopressor requirements in human septic shock and affects anaphylatoxin levels differently than standard CVVHKeywords
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